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Published on:2, 2011
Pharmacognosy Journal, 2011; 3(20):38-41
Original Article | doi:10.5530/pj.2011.20.8

Evaluation of antiulcer activity of various extracts of Semecarpus anacardium seeds

Authors and affiliation (s):

Kumar Manoj*, Jangra Meenu1, Sharma Sunil2

*1Lecturer, Department of Pharmacy, Saroj Institute of Engg. & Management, Lucknow,

2Asst. Prof., Guru Jambheshwar University of Sc. & Tech , Hisar, India.


Methanolic and aqueous extracts of Semecarpus anacardium seeds were investigated for gastric protective activity on ethanol plus pylorus ligation induced ulcer models. A number of biochemical parameters such as gastric volume, pH of gastric content, free acidity and total acidity, dissolved mucous substances such as total protein, hexoses, hexosamine, fucose and sialic acid were estimated in 90% alcoholic precipitate of gastric juice and macroscopically sections were examined on the test and control group animals. The extract at a concentration of 200mg/kg produced a protective effect on ulcer-induced models and was comparable with the standard drug cimetidine. Some of the antioxidant enzyme levels (lipid peroxidation, superoxide dismutase and catalase) were also determined. The present study revealed that the methanolic extract of Semecarpus anacardium had ulcer protective activity comparable with standard drug cimetidine.

Key words: S. anacardium, ulcer, Ethanol plus pylorus ligation, Biochemical parameters, Methanolic extract.


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