Home | Articles
Published on:4, 2011
Pharmacognosy Journal, 2011; 3(21):36-48
Original Article | doi:10.5530/pj.2011.21.7

Cytotoxicity and Antioxidant Activity of New Biologically Active Constituents from Salvia Lanigra and Salvia Splendens


Authors and affiliation (s):

Usama Y. Shaheen1*, Mohammed H. Hussain1 and Hassan A. Ammar2

1 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

2 Department of Pharmacognosy, Faculty of Pharmacy, Ahram Canadian University in Egypt, 6th October, Egypt.

Abstract:

Chromatographic fractionation of the acetone extracts of each of Salvia lanigra and Salvia splendens and of the n-butanol extract of Salvia lanigra, resulted in the isolation and identification of two known diterpenes; horminone (1) and 7-O-ethylhorminone (2), three new diterpenes; salviatane B (3), salvianol A (4) and salviaclerodan A (5), two known triterpenioc acids; ursolic acid (6) and oleanolic acid (7), a known sterol; β-sitosterol (8), two known flavones; salvigenin (9) and apigenin (10) and one new caffiec acid dimmer; 3,3’-dehydrodicaffeic acid (11). The cytotoxicity and the antioxidant activity of the different extracts (MeOH, acetone and n-butanol) of both Salvia lanigra and Salvia splendens and most of the isolated pure compounds (1-5, 9 and 10) were determined.

Key words: Salvia, Diterpenes, Phenolics, Cytotoxicity and Antioxidants Activity.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.