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Published on:4, 2011
Pharmacognosy Journal, 2011; 3(21):36-48
Original Article | doi:10.5530/pj.2011.21.7

Cytotoxicity and Antioxidant Activity of New Biologically Active Constituents from Salvia Lanigra and Salvia Splendens

Authors and affiliation (s):

Usama Y. Shaheen1*, Mohammed H. Hussain1 and Hassan A. Ammar2

1 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

2 Department of Pharmacognosy, Faculty of Pharmacy, Ahram Canadian University in Egypt, 6th October, Egypt.


Chromatographic fractionation of the acetone extracts of each of Salvia lanigra and Salvia splendens and of the n-butanol extract of Salvia lanigra, resulted in the isolation and identification of two known diterpenes; horminone (1) and 7-O-ethylhorminone (2), three new diterpenes; salviatane B (3), salvianol A (4) and salviaclerodan A (5), two known triterpenioc acids; ursolic acid (6) and oleanolic acid (7), a known sterol; β-sitosterol (8), two known flavones; salvigenin (9) and apigenin (10) and one new caffiec acid dimmer; 3,3’-dehydrodicaffeic acid (11). The cytotoxicity and the antioxidant activity of the different extracts (MeOH, acetone and n-butanol) of both Salvia lanigra and Salvia splendens and most of the isolated pure compounds (1-5, 9 and 10) were determined.

Key words: Salvia, Diterpenes, Phenolics, Cytotoxicity and Antioxidants Activity.


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