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Published on:4, 2011
Pharmacognosy Journal, 2011; 3(21):60-64
Original Article | doi:10.5530/pj.2011.21.10

Role of Melia azedarach leaf extract in Paracetamol Induced Hepatic damage in rats


Authors and affiliation (s):

Mohammed Fazil Ahmed*1, A. Srinivasa Rao2, Hameed Thayyil1, Shaik Rasheed Ahemad1 and Mohammed Ibrahim1

1Nizam Institute of Pharmacy & Research Center, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda,(AP), INDIA-508284.

2Bhaskar Pharmacy College,Yeknapally, Moinabad(Mandal), R.R(Dist), Hyderabad-500075.

Abstract:

The hepataprotective activity of the methanolic leaf extract of Melia azedarach was investigated against paracetamol induced hepatic damage in rats. Over dosing of paracetamol to rats is reported to decrease the activity of antioxidative enzymes (GPx, GST, SOD and CAT ) in liver and increase the serum enzymes (SGOT , SGPT and Alkaline phosphate), bilirubin and decrease the total proteins content. Melia azedarach leaf extract maintained the activity of antioxidant enzymes and as well as serum enzymes to the normal level. Thus the present study ascertains that the leaf extract of Melia azedarach possesses significant hepatoprotective activity.

Key words: Hepatoprotective, Hepatic damage, Methanolic leaf extract, Melia azedarach, Serum enzymes and Antioxidant enzymes.

 

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