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Published on:9, 2011
Pharmacognosy Journal, 2011; 3(25):18-20
Original Article | doi:10.5530/pj.2011.25.3

Identification of a Bioactive Compound from Myrcianthes cysplatensis


Authors and affiliation (s):

Eugenio D´Amicoa#, Stephanie Barnechea, Maria Pia Cerdeirasb and Alvaro Vázqueza*

aCátedra de Farmacognosia y Productos Naturales, Facultad de Química, UdelaR, Montevideo, Uruguay.

bCátedra de Microbiología, Facultad de Química, Udelar, Montevideo, Uruguay.

#Permanent address: Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Bologna, Italy.

Abstract:

Myrcianthes cisplatensis (Cambess.) O. Berg (Myrtaceae) grows freely in Uruguay especially in the banks of rivers and streams. It is locally known as guayabo colorado and it´s fruits are edible and used for the preparation of marmalades. In this work we present the results of the bioguided isolation and structural elucidation of the main active compound as well as it´s antibacterial activity. Through repeated chromatography a pure compound could be obtained. The compound was studied by different spectroscopic techniques and could be unambiguously identified as α-methyl-1-(2´, 4´, 6,-trimethoxyphenyl)-1-propanone. When assaying for antistaphylococcal activity, it showed MICs of 62.5 μg/mL for the sensible strain (ATCC 6538p) and 250 μg/mL for the multirresistant ones (ATCC 43300 and ATCC 700699). This shows that the bioguided fractionation is appropriate even when not very active compounds are isolated.

Key words: Myrcianthes cysplatensis, Staphylococcus aureus.

 

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