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Published on:18th Feb,2014
Pharmacognosy Journal, 2014; 6(1):43-46
Original Article | doi:10.5530/pj.2014.1.7

15-Lipoxygenase inhibition of selected Philippine medicinal plants


Authors and affiliation (s):

Noemi D. Paguigan1 and Christine L. Chichioco-Hernandez*,2

1Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City, Philippines 1101

2Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City, Philippines 1101

Abstract:

Several extracts from Philippine medicinal plants used for asthma and other inflammatory diseases were evaluated for their ability to inhibit the action of 15-lipoxygenase. The inhibitory activity was tested spectrophotometrically using quercetin as positive control. Eleven species belonging to 11 families displayed varying inhibitory activities. Commelina diffusa and Euphorbia hirta showed the highest inhibitory activity at 51.3% and 48.5%, respectively. These plants may contain new 15-lipoxygenase inhibitors.

Key words: Asthma, inflammation, lipoxygenase, medicinal plants, plant extra.

 

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