Pharmacognosy Journal, 2012; 4(27):56-59
Original Article | doi:10.5530/pj.2012.27.9
Antihyperglycemic Effect of Meryta denhamii Seem. Fruits and Phytochemical study of its Saponin Content
Abstract:
In this study Meryta denhamii Seem. fruits (Araliaceae) were tested for the antihyperglycemic effect against alloxan induced hyperglycemia in rats using metformin as standard drug. The alcoholic extract and n-butanol fraction (saponins rich fraction) of the fruits exhibited significant antihyperglycemic effect (42.8 and 38.4 % of change, respectively, comparing to 67.1% for metformin). The n-butanol fraction was subjected to chemical study which resulted in isolation of four monodesmosidic oleanane saponins. Their structures were established based on their MS, 1H-NMR and 13C-NMR spectral data as 3-O-[β-D-glucopyranosyl] oleanolic acid, 3-O-[α-D-glucuronopyranosyl] oleanolic acid, 3-O-[β-Dglucopyranosyl-( 1-3)-α-L-arabinofuranosyl] oleanolic acid and 3-O-[α-L-arabinofuranosyl-(1-4)-β-D-glucuronopyranosyl] oleanolic acid.
Key words: Meryta denhamii Seem. fruits, triterpenoid saponins, oleanane saponins, antihyperglycemic.
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Vancouver Style:
Antihyperglycemic Effect of Meryta denhamii Seem. Fruits and Phytochemical study of its Saponin Content. Pharmacognosy Journal. 2012;4(27):56-9. Abstract
AMA Style:
"Antihyperglycemic Effect of Meryta denhamii Seem. Fruits and Phytochemical study of its Saponin Content." Pharmacognosy Journal. 2012;4(27):56-59. Abstract
CSE Style:
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2012. Antihyperglycemic Effect of Meryta denhamii Seem. Fruits and Phytochemical study of its Saponin Content. Pharmacognosy Journal. 4(27):56-59. Abstract