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Published on:11th Feb, 2012
Pharmacognosy Journal, 2012; 4(27):56-59
Original Article | doi:10.5530/pj.2012.27.9

Antihyperglycemic Effect of Meryta denhamii Seem. Fruits and Phytochemical study of its Saponin Content


Authors and affiliation (s):

Enas H. Abdel Rahman, Azza R. Abdel Monem*, Amany A. Sleem1

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

1Pharmacology Department, National Research Centre, Giza 12622, Egypt.

Abstract:

In this study Meryta denhamii Seem. fruits (Araliaceae) were tested for the antihyperglycemic effect against alloxan induced hyperglycemia in rats using metformin as standard drug. The alcoholic extract and n-butanol fraction (saponins rich fraction) of the fruits exhibited significant antihyperglycemic effect (42.8 and 38.4 % of change, respectively, comparing to 67.1% for metformin). The n-butanol fraction was subjected to chemical study which resulted in isolation of four monodesmosidic oleanane saponins. Their structures were established based on their MS, 1H-NMR and 13C-NMR spectral data as 3-O-[β-D-glucopyranosyl] oleanolic acid, 3-O-[α-D-glucuronopyranosyl] oleanolic acid, 3-O-[β-Dglucopyranosyl-( 1-3)-α-L-arabinofuranosyl] oleanolic acid and 3-O-[α-L-arabinofuranosyl-(1-4)-β-D-glucuronopyranosyl] oleanolic acid.

Key words: Meryta denhamii Seem. fruits, triterpenoid saponins, oleanane saponins, antihyperglycemic.

 

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