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Published on:11th Feb, 2012
Pharmacognosy Journal, 2012; 4(27):56-59
Original Article | doi:10.5530/pj.2012.27.9

Antihyperglycemic Effect of Meryta denhamii Seem. Fruits and Phytochemical study of its Saponin Content

Authors and affiliation (s):

Enas H. Abdel Rahman, Azza R. Abdel Monem*, Amany A. Sleem1

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

1Pharmacology Department, National Research Centre, Giza 12622, Egypt.


In this study Meryta denhamii Seem. fruits (Araliaceae) were tested for the antihyperglycemic effect against alloxan induced hyperglycemia in rats using metformin as standard drug. The alcoholic extract and n-butanol fraction (saponins rich fraction) of the fruits exhibited significant antihyperglycemic effect (42.8 and 38.4 % of change, respectively, comparing to 67.1% for metformin). The n-butanol fraction was subjected to chemical study which resulted in isolation of four monodesmosidic oleanane saponins. Their structures were established based on their MS, 1H-NMR and 13C-NMR spectral data as 3-O-[β-D-glucopyranosyl] oleanolic acid, 3-O-[α-D-glucuronopyranosyl] oleanolic acid, 3-O-[β-Dglucopyranosyl-( 1-3)-α-L-arabinofuranosyl] oleanolic acid and 3-O-[α-L-arabinofuranosyl-(1-4)-β-D-glucuronopyranosyl] oleanolic acid.

Key words: Meryta denhamii Seem. fruits, triterpenoid saponins, oleanane saponins, antihyperglycemic.


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