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Published on:7, 2012
Pharmacognosy Journal, 2012; 4(30):30-33
Original Article | doi:10.5530/pj.2012.30.6

Antithrombolytic and Antidiabetic Activity of Methanolic Extract of Paederia foetida


Authors and affiliation (s):

Helal Morshed,1 Muhammad Shahdaat Bin Sayeed,2* A G M Mostofa,3 Md.Siddiqul Islam,4 Salma Parvin5

1Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.

2Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka-1000, Bangladesh.

3Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka-1000, Bangladesh.

4Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka-1000, Bangladesh.

5Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka-1000, Bangladesh.

Abstract:

Present study was carried out to investigate the antidiabetic and antithrombolytic properties of methanolic extracts of the whole plant of Paederia foetida. Alloxan-induced male Sprague Dawley (SD) rats were given the whole plant extract of methanol by gastric gavage at doses of 250, 500, 1000 mg/kg body wt. and the results of reduction of blood glucose levels were compared with negative control (Tween 80 solution) & positive control (Glibenclamide). Methanolic extracts of the whole plant of P. foetida has moderate antidiabetic activity. At the 3rd hour, the dose of 250, 500 and 1000 mg/kg decreased the blood glucose levels by 31.6%, 28% and 30.3%, respectively, while the reference drug (glibenclamide, 2 mg/kg) decreased the blood glucose level by 70%. 100 μl extract of P. foetida exhibited the highest thrombolytic activity (among three samples) with clot lysis value of 23.82% whereas standard streptokinase (positive control) and water (negative control) demonstrated clot lysis value of 45.85% and 2.81%, respectively.

Key words: paederia foetida , antithrombolytic activity, antidiabetic activity, methanol extract.

 

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