Antithrombolytic and Antidiabetic Activity of Methanolic Extract of Paederia foetida

Abstract:

Present study was carried out to investigate the antidiabetic and antithrombolytic properties of methanolic extracts of the whole plant of Paederia foetida. Alloxan-induced male Sprague Dawley (SD) rats were given the whole plant extract of methanol by gastric gavage at doses of 250, 500, 1000 mg/kg body wt. and the results of reduction of blood glucose levels were compared with negative control (Tween 80 solution) & positive control (Glibenclamide). Methanolic extracts of the whole plant of P. foetida has moderate antidiabetic activity. At the 3^rd hour, the dose of 250, 500 and 1000 mg/kg decreased the blood glucose levels by 31.6%, 28% and 30.3%, respectively, while the reference drug (glibenclamide, 2 mg/kg) decreased the blood glucose level by 70%. 100 μl extract of P. foetida exhibited the highest thrombolytic activity (among three samples) with clot lysis value of 23.82% whereas standard streptokinase (positive control) and water (negative control) demonstrated clot lysis value of 45.85% and 2.81%, respectively.

Key words: paederia foetida , antithrombolytic activity, antidiabetic activity, methanol extract.