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Published on:3rd Sept, 2014
Pharmacognosy Journal, 2014; 6(6):5-9
Original Article | doi:10.5530/pj.2014.6.2

Estrogenic Activity of Bauhinia racemosa extract in Female albino rats: An Investigational Study


Authors and affiliation (s):

Gautam P. Vadnere1*, Aslam R. Pathan1, Abhay K. Singhai2

1Department of Pharmaceutical Sciences, SMT SS Patil College of Pharmacy, North Maharashtra University, Chopda, Jalgaon, Maharashtra, India,

2Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Vishwavidyalaya, Sagar, Madhya Pradesh, India.

Abstract:

Objective: To evaluate the effect of petroleum ether, ethanol and water extract of Bauhinia racemosa in female albino rats. Methods: Plant extracts were tested for their estrogenic activity by using ovariectomised method at two dose level: 200 mg/kg and 400mg/kg respectively. Further, Plant extracts and Standard drug Ethinyl estradiol (1µg/kg) combination were tested for synergistic estrogenic activity. Results: In-vivo investigation revealed that ethanol extract at dose of 200 mg/kg and 400 mg/kg shows significance increase 325.23±5.23, 328.84±4.56 and 3.252±0.47, 3.288±0.27 in uterine wet weight and uterine weight ratio respectively in female albino rat as compared to control and petroleum ether and water extracts. Simultaneous administration of standard drug Ethinyl estradiol (1µg/kg) with ethanol extract at dose of 200 mg/kg and 400 mg/ kg potentiates (327.36 ± 5.78, 330.95 ± 6.21 and 3.273 ± 0.64, 3.309 ± 0.49 uterine wet weight and uterine weight ratio respectively in female albino rat) the estrogenic activity as compared to individual administration of ethanol extract as a synergistic effect. Conclusion: It was observed that ethanol extract of Bauhinia racemosa produced significance estrogenic activity.

Key words: Bauhinia racemosa, estrogenic activity, Ethinyl estradiol, ovariectomy.

 

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