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Published on:18th Sep,2014
Pharmacognosy Communications, 2014; 4(4):64-70
Research Article | doi:10.5530/pc.2014.4.7

Experimental evaluation of the hepatoprotective effect of Butea monosperma extract on antitubercular drugs induced hepatotoxicity


Authors and affiliation (s):

Nisha Sonkar, Priyanka Yadav, Divya Bansal1, Aditya Ganeshpurkar* and Nazneen Dubey

*Drug Discovery Laboratory, Department of Pharmacy, Shri Ram Institute of Technology, Jabalpur, M.P., India

1Pharmaceutics Research Laboratory, Department of Pharmacy, Shri Ram Institute of Technology, Jabalpur, M.P., India

Abstract:

Context: Haphazard use of drugs is one of the key reason for progression of liver diseases. Drugs such as paracetamol, isoniazid, rifampicin etc cause hepatotoxicity. However, there is currently no single synthetic drug which is effective for the treatment of such conditions. Drugs from natural sources have been used by humans from eternal era. Thus, plants serve to be an important source to explore hepatoprotectives. Objective: The current study was designed to assess the hepatoprotective activity of Butea monosperma extract. Materials and methods: Leaves of B. monosperma were dried in shade, powdered and extracted with ethanol and phytochemical screening was performed. The extract phenolic and flavonoids contents were estimated. The extract was also subjected to acute toxicity studies as per OECD guidelines. Hepatoprotective studies were performed using isoniazid- rifampicin induced hepatotoxicity in rats. Results: Results of the phytochemical tests and phytoanalytical studies demonstrated that the extract was rich in flavonoids, glycosides and polyphenolics. The extract also demonstrated excellent hepatoprotective activity against isoniazid- rifampicin induced hepatotoxicity in rats. Discussion and conclusion: Results of study demonstrate that ethanol extract of B. monosperma is potent source of phytochemicals that are responsible to demonstrate hepatoprotective activity.

Key words: liver, Butea monosperma, hepatoprotective, SGPT, SGOT, ALP

 

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