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Published on:09th Mar, 2015
Pharmacognosy Journal, 2015; 7(3):178-181
Original Article | doi:10.5530/pj.2015.3.6

Flavonoids from Eupatorium illitum and Their Antiproliferative Activities


Authors and affiliation (s):

Quírico A Castillo*1,2, Jorge Triana3, José L Eiroa3, José M Padrón4, Gabriela B Plata4, Ernesto V Abel-Santos5, Luis A. Báez1, Diana C Rodríguez1, Marco A Jiménez2, María F Pérez-Pujols1

1Escuela de Química, Facultad de Ciencias, Universidad Autónoma de Santo Domingo, Ciudad Universitaria, Santo Domingo D.N., Dominican Republic.

2Instituto de Química, Facultad de Ciencias, Universidad Autónoma de Santo Domingo, Ciudad Universitaria, Santo Domingo D.N., Dominican Republic.

3Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.

4BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), C/Astrofísico Francisco Sánchez 2, 38206. La Laguna, Spain.

5Department of Chemistry and Biochemistry, University of Nevada-Las Vegas, Las Vegas, NV 89154.

Abstract:

Objective: To isolate the chemical constituents of the aerial parts from Eupatorium illitum, elucidate their structures and evaluate their antiproliferative activity on human cancer cell lines. Materials and Methods: The ethanolic extract of Eupatorium illitum afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of selected isolates were evaluated. Results: The flavonoids Kumatakenin (1), Ermanin (2), 7-methoxy-aromadendrin (3) and Naringenin (4), together with 4-hydroxybenzoic acid (5) were isolated. Compounds 1, 2, 4 and 5 were evaluated for their antiproliferative activity on the human cancer cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), and T-47D (breast) presenting a wide range of bioactivities. In general, best results were observed for 5. Conclusion: Compounds 1-5 are reported for first time from Eupatorium illitum. Isolated phytochemicals show moderate to low antiproliferative activities when evaluated on the aforementioned human cancer cell lines.

Key words: Eupatorium illitum, Ermanin, 4-Hydroxybenzoic acid, Kumatakenin, 7-Methoxy-aromadendrin, Naringenin.

 

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