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Pharmacognosy Journal, 2013; 5(1):13-16
Research Article | doi:10.1016/j.phcgj.2012.12.001

Anti-inflammatory and analgesic evaluation of hydroalcoholic extract and fractions from seeds of Piper cubeba L. (Piperaceae)

Authors and affiliation (s):

F.F. Perazzoa,b,c, I.V. Rodriguesd, E.L. Maistroe, S.M. Souzad, N.P.D. Nanaykkarac, J.K. Bastosa, J.C.T. Carvalhob, G.H.B. de Souzaa,d,*

aFaculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, SP, CEP 14040-903, Brazil

bDepartamento de Ciências Exatas e da Terra, UNIFESP, Diadema, SP, CEP 09972-270, Brazil

cNational Center for Natural Products Research, School of Pharmacy, The University of Mississippi, MS 38677, USA

dLab. de Farmacognosia, Escola de Farmácia, UFOP, Ouro Preto, MG, CEP 35400-000, Brazil

eFaculdade de Filosofia e Ciências, Departamento de Fonoaudiologia, UNESP, Marília, SP, CEP 17525-900, Brazil


Some of the Piper species have been applied for the treatment of several diseases (anti-oxidant, antimicrobial, anti-inflammatory, and analgesic), considering multiple applications used in traditional medicine of different countries. About these, the present study evaluated some biological activities of Piper cubeba, as writhing test induced by acetic acid, ear edema induced by croton oil and paw edema induced by carrageenan were used by evaluated the analgesic and anti-inflammatory activities of crude hydroalcoholic extract (PCE) and its fractions of different polarities of P. cubeba L. seeds. The lethal dose (LD50) and the effective dose (ED50) were evaluated too. Both the PCE and dichloromethane fraction showed decrease values of edema and abdominal constrictions. The results obtained in this study confirm the low toxicity and analgesic and anti-inflammatory activities of PCE from P. cubeba seeds, justifying its use in folk medicine.

Key words: Piper cubeba, Piperaceae, Anti-inflammatory, Analgesic.


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