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Pharmacognosy Journal, 2013; 5(1):6-12
Research Article | doi:10.1016/j.phcgj.2012.08.001

Antiedematogenic and antinociceptive effects of leaves extracts from Protium spruceanum Benth. (Engler)

Authors and affiliation (s):

Ivanildes V. Rodriguesa, Juliana N. de P. Souzaa, Ana Cláudia G. Silvaa, Lucas A. Chiblia, Vivette A.R. Cabralb, Sidney A. Viera Filhoa, Fábio F. Perazzoc, Andrea G. Guimarãesa, Gustavo H.B. de Souza a,*

aDepartamento de Farmácia, Escola de Farmácia, CIPharma, Universidade Federal de Ouro Preto, Rua Costa Sena, 171, Centro, Ouro Preto 35400-000, MG, Brazil

bDepartamento de Ciências Florestais, Universidade Federal de Lavras, Campus Universitário, Jardim Eldorado, Lavras 37200-000, MG, Brazil

cDepartamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo, Rua Arthur Riedel, 275, Jardim Eldorado, Diadema 09072-270, SP, Brazil


Ethnopharmacological relevance: In traditional medicine, gums and oil-resins from Protium species have been used for many diseases, however, there are no reports of studies of Protium spruceanum leaves. Materials and methods: The antiedematogenic and antinociceptive effects of crude ethanol extract (EEB) from leaves of P. spruceanum and its fractions were evaluated in biological models. The fractions were obtained with hexane (FHEX) and methanol (FMEOH). Rat paw edema induced by carrageenan, writhing test, formalin test, hot plate test and the toxicity of EEB were performed. Results: Phytochemical analysis has shown the presence of ∝ and β-amyrins as major constituents of FHEX. Promising results of anti-inflammatory and antinociceptive activity were found for EEB, FHEX and FMEOH. Also were observed the EEB at 6000 mg/kg showed no toxicity. Conclusion: One might suggest that the activities of FHEX are due to the presence of a and b-amyrins and contributes to the biological activities of EEB.

Key words: Protium spruceanum, Burseraceae, Antiedematogenic, Antinociceptive.


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