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Pharmacognosy Journal, 2013; 5(6):256-258
Original Article | doi:10.1016/j.phcgj.2013.10.004

Antiepileptic activities of the extract and fractions of Mondia whitei (Hook f.) Skeel leaves


Authors and affiliation (s):

Adediwura A. Fred-Jaiyesimi*, Oluwatosin F. Ogunjobi

Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu Campus, Ogun State, Nigeria

Abstract:

Objectives: To investigate the antiepileptic potentials of Mondia whitei (Hook f.) Skeel leaves as identified in the folklore recipes for the management of paralysis, epilepsy. M. whitei is also used in antimalarial, antihelminthic recipes as well as in the treatment of impotence and sexual dysfunction. Methodology: The antiepileptic study of the methanol extract, hexane and ethyl acetate fractions were carried out using the pilocarpine induced seizure model while the Phytochemical and fluorescence analysis were carried out using standard procedures. Result: The presence of saponins, flavonoids, tannins and resins were detected in the leaves of M. whitei. The extract and fractions exhibited a dose-dependent effect in the delay of the onset of seizures and reduction in the duration of seizure. Conclusion: This study justifies the use of M. whitei in folklore medicine as a recipe in the management of epilepsy.

Key words: Mondia whitei, Epilepsy, Pilocarpine, Phytochemical and fluorescence analysis.

 

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