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Pharmacognosy Journal, 2013; 5(5):221-227
Original article | doi:10.1016/j.phcgj.2013.08.001

Antihyperlipidemic effect of Angiosifa, a polyherbal formulation, in Sprague-Dawley rats


Authors and affiliation (s):

Subramani Parasuramana,*, Seevalen Shahul Hamid Babujia, Gan Siaw Thingb, Kuppusamy Sreevidya Kumarib, Athitan Yoganishalinb, Chua Wei Lianb, Manimaran Kumuthab, Tajudeen Kassimc, Sokkalingam Arumugam Dhanarajd

aUnit of Pharmacology, Faculty of Pharmacy, Asian Institute of Medicine, Science and Technology (AIMST) University, Bedong 08100, Kedah, Malaysia

bFaculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia

cEast West Oriental Enterprises, No. 36 B, Chow Thye Road, Penang 10050, Malaysia

dUnit of Pharmaceutical Technology, Faculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia

Abstract:

Objective: To study the antihyperlipidemic effect of Angiosifa, a polyherbal formulation (PHF), in Spraguee Dawley (SD) rats. Methods: The rats were divided into seven groups, each having five animals: normal controls, high fat diet (HFD)-fed controls and HFD-fed animals treated with atorvastatin (10 mg/kg), petroleum ether extract of the PHF (200 and 400 mg/kg) and methanol extract of the PHF (200 and 400 mg/kg). The test and standard drugs were administered orally once daily for 28 consecutive days. During the experiment, changes in body weight were noted and alterations in biological and biochemical parameters were monitored at regular intervals. Results: HFD-fed animals showed significant increases in body weight and total cholesterol, triglyceride and VLDL levels. They also showed a significant reduction in HDL levels compared with the control and drug treatment groups. Animals treated with atorvastatin and methanol extract of PHF showed significant reductions in total cholesterol, triglyceride and VLDL levels compared with HFD-fed animals. But there was no significant hypolipidemic effect in animals treated with petroleum ether extract of PHF, and the ether caused piloerection and led to cannibalism. Conclusion: Methanol extract of PHF has a significant hypolipidemic effect against HFD-induced hyperlipidemia in SD rats. The petroleum ether extract of PHF did not show any significant hypolipidemic effect on HFD-fed rats.

Key words: Hypolipidemia, Petroleum, ether Piloerection, Cutis anserina.

 

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