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Pharmacognosy Journal, 2013; 5(5):197-204
Original article | doi:10.1016/j.phcgj.2013.09.001

Chemical characterisation and antifungal activity of methanolic extract of Cinnamomum verum J. Presl bark against Malassezia spp.


Authors and affiliation (s):

Prabha Manju Mariappana, *, Gokulshankar Sabesanb, Babu Koilpillaic, Sudha Janakiramand, Navin Kumar Sharmac

aDepartment of Biotechnology, Acharya Nagarjuna University, Guntur, Andhra Pradesh 522 510, India

bMicrobiology Unit, Faculty of Medicine, AIMST University, Bedong, Kedah 08100, Malaysia

cR & D Centre, Cholayil Private Limited, Chennai 600 098, Tamil Nadu, India

dDepartment of Microbiology, Mohammed Sathak College of Arts and Science, Chennai 600119, Tamil Nadu, India

Abstract:

Context: Malassezia spp. are the organisms causing skin infections like dandruff, pityriasis versicolor, seborrhoeic dermatitis etc. in human and in animals. Using natural ingredients for treating these diseases could be a better task. Aim: To investigate the phytochemical constituents and antifungal efficacy of Cinnamomum verum (CV) bark methanolic extract against dandruff, pityriasis versicolor, seborrhoeic dermatitis causing dimorphic fungi belonging to the genus Malassezia. Materials and methods: Cultures of Malassezia globosa, Malassezia sympodialis, and Malassezia furfur of clinical origin were prepared by adjusting inoculum size to 108 cfu/ml. Minimum inhibitory concentration (MIC) and zone of inhibition (ZOI) for methanolic extract of CV bark were done to find out the lowest concentration of extract required to inhibit the growth of Malassezia spp. and the preliminary phytochemical and GCeMS analysis was carried out to identify the phytoconstituents. Results: Methanolic extract of bark of CV showed MIC value ranging from 0.5 to 2 mg/ml against Malassezia spp. The major chemical constituents were identified as trans-Cinnamaldehyde (20.28%), (E)- 3-(2-Methoxyphenyl)-2-propenoic acid (40.41%), 4-Vinyl benzoic acid (10.54%) and coumarin (8.47%) by GCeMS. Conclusion: C. verum bark methanolic extract has potential antifungal activity and can be exploited against skin infections caused by M. globosa, M. sympodialis, and M. furfur.

Key words: Anti-malassezial, Antifungal, Cinnamomum verum, Cinnamon Bark, Cinnamaldehyde.

 

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