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Pharmacognosy Journal, 2013; 5(3):127-129
Short Communication | doi:10.1016/j.phcgj.2013.04.005

Cytotoxic effect of Anthocephalus cadamba Miq. leaves on human cancer cell lines


Authors and affiliation (s):

Satyajit Singha,c, Mohan Paul Singh Ishara, Ajit Kumar Saxenad, Arvinder Kaura,b,*

aDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, India

bDepartment of Pharmacy, Government Polytechnic College, Amritsar 143001, India

cBioorganic Chemistry Laboratory, Department of Pharmaceutical Chemistry, Khalsa College of Pharmacy, Amritsar 143002, India

dPharmacology Division, Indian Institute of Integrated Medicine, Jammu Tawi 180006, India

Abstract:

Introduction: Anthocephalus cadamba Miq. (Rubiaceae) is used as folk medicine in the treatment of fever, anemia, leprosy, dysentery, blood and skin diseases. Methods: Powdered leaves of A. cadamba were extracted sequentially with hexane, chloroform, ethanol, ethanol:water (50:50) and water by maceration, and evaluated for cytotoxic potential using SRB assay against four human cancer cell lines lung (A-549), ovary (IGR-OV-1), prostate (PC-3) and CNS (SF-295). Results: Chloroform extract exerts potent cytotoxic effect against human lung (A-549), ovary (IGR-OV-1), prostate (PC-3) and CNS (SF-295) cancer cell lines IC50 of 8, 57, 49 and 39 mg/ml respectively. Ethanolic extract was found to be active only against one cell line CNS (SF-295). Conclusion: The present study demonstrates the cytotoxic potential of A. cadamba leaves extract (chloroform) against different human cancer cell lines.

Key words: Anthocephalus cadamba,Cytotoxicity,Rubiaceae,Lung (A-549).

 

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