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Pharmacognosy Journal, 2013; 5(1):2-5
Research Article | doi:10.1016/j.phcgj.2012.09.001

Cytotoxic effects of Anagallis arvensis and Anagallis foemina in neuronal and colonic adenocarcinoma cell lines

Authors and affiliation (s):

Víctor Lópeza,*, Rita Yolanda Caverob, Maria Isabel Calvoc

aDepartment of Pharmacy, Faculty of Health Sciences, San Jorge University, Autovía A-23 Zaragoza-Huesca km. 299, 50830 Villanueva de Gállego (Zaragoza), Spain

bDepartment of Plant Biology, School of Sciences, University of Navarra, Irunlarrea sn, 31008 Pamplona, Spain

cDepartment of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Irunlarrea sn, 31008 Pamplona, Spain


Anagallis arvensis L. and Anagallis foemina Mill. (Primulaceae) have been used in Navarra (Spain) as wound healing remedies within a context of traditional medicine. The species have previously demonstrated antimicrobial and COX-inhibiting properties. Cytotoxic effects of the plants have never been established though they are popularly known to be toxic at high doses and/or long term oral administration. Cytotoxicity was evaluated in PC12 and DHD/K12PROb cells using spectrophotometric methods such as the MTT and LDH assays. Both plants reduced cell survival and induced cell damage (LDH release) in a dose-dependent manner, PC12 cells being more sensitive to the extracts than DHD/K12PROb cells. Methanol extracts were significantly more cytotoxic and doses over 80 µg/ml reduced cell survival above 50%. Results suggest that these plants may be responsible for the toxic effects that have been described in traditional medicine.

Key words: Anagallis,Primulaceae,Medicinal plants,Traditional medicine,Cytotoxicity.


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