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Pharmacognosy Journal, 2013; 5(1):17-21
Research Article | doi:10.1016/j.phcgj.2012.12.002

Efficacy and structural effects of Acacia pennata root bark upon the avian parasitic helminth, Raillietina echinobothrida


Authors and affiliation (s):

Kholhring Lalchhandama

Department of Zoology, Pachhunga University College, Mizoram University, Aizawl 796 001, Mizoram, India

Abstract:

Introduction: Acacia pennata (L.) Willd. is a well-known shrub in the south and southeast Asian regions, where the natives use it for a wide range of purposes from medicines to culinary cuisines. Among the Mizo tribes of India the plant is used in the treatment of gastrointestinal infections. Methods: To validate this traditional practice, a defined set of poultry tapeworm, Raillietina echinobothrida, was treated with varying concentration viz. 1, 2, 5, 10, and 20 mg/mL, of the methanol extract of the root bark. Similar treatment was concurrently performed for a broad-spectrum drug albendazole, in corresponding concentrations. Results: Assessment of the survival indicated that the plant extract caused concentration-dependent effects comparable to that of albendazole, with significant mortality (P < 0.5 by student’s t-test) of the test worms at all concentrations tested in comparison with those of the control group. Morphological observations using scanning electron microscope revealed that the tapeworms in the 20 mg/mL plant extract treatment group exhibited profound structural damages. The scolex became massively shrunken, with the special attachment organs reduced to crooked appendages. Overall deformation of the tegument was apparent throughout the body surface. All the body segments shrivelled up, deflated and wrinkled into fluffy folds. The fine hairy microtriches completely disappeared, and replaced by an irregular mass of conglomerate tissues. Conclusion: The study shows that A. pennata has an anthelmintic property that requires further investigations as to the nature and mode of action of the active compounds

Key words: Anthelmintic,Albendazole,Medicinal plants,Scolex,Tegument

 

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