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Pharmacognosy Journal, 2013; 5(6):265-268
Original Article | doi:10.1016/j.phcgj.2013.09.005

Phytochemical and GC-MS analysis of bioactive compounds of Sphaeranthus amaranthoides Burm

Authors and affiliation (s):

Somnath Dea,*, Akalanka Deyb, A.M.S. Sudhakar Babuc, Siddabathuni Aneelaa

aDr. Samuel George Institute of Pharmaceutical Sciences, Markapur 523316, Andhra Pradesh, India

bAnnamalai University, Department of Pharmacy, Tamil Nadu 600 802, India

c A.M. Reddy Memorial College of Pharmacy, Guntur 522601, Andhra Pradesh, India


Objective: To isolate and analyze the phytochemical constituents of Sphaeranthus amaranthoides using GCeMS. Method: Preliminary phytochemical screening of the extract was carried out according to the standard method described by Brindha et al. GCeMS analysis was performed on the methanolic extract of S. amaranthoides to find out the chemical constituents. Results: Phytochemical screening revealed the presence of steroids, alkaloids, sugars, phenolics, flavonoids, saponins, tannins and amino acids with mottled degree. GCeMS results revealed the presence of 23 different phytocompounds viz., 2-Propenoic acid, 2-methyl-, 2-[[2,3,3a,4,7,7a(or 3a,4,5,6,7,7a)-hexahydro- 4,7-methano-1H-indenyl]oxy] ethyl ester (32.73%), Methanone, (1-hydroxycyclohexyl)phenyl - (13.71%), Methyl 2-bromomethyl-10-tetrahydropyranyloxy-2-decenoate - (7.84%),4,7-Methano-1Hindene, 3a,4,5,6,7,7a-hexahydro-5-(2-propenyloxy) - (6.27%), Primidone - (4.50%), 2-Propenoic acid, 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl ester, exo -(3.78%) and normorphine, bis(o-trimethylsilyl) -(3.65%) etc. Conclusion: The presence of various bioactive compounds confirms the application of S. amaranthoides for various diseases by traditional practitioners. However, isolation of individual phytochemical constituents may proceed to find a novel drug.

Key words: Asteraceae, GCeMS study, Methanol extract, Soxhlet extractor.


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