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Published on:3rd August, 2012
Pharmacognosy Journal, 2012; 4(31):01 -04
Original Article | doi:10.5530/pj.2012.31.1

Chemical constituents of Broussonetia luzonicus

Authors and affiliation (s):

Tsai Po-wei1, De Castro-Cruz Kathlia A1, Shen Chien-Chang2 and Ragasa Consolacion Y3,*

1School of Chemical Engineering and Chemistry, Mapúa Institute of Technology, Muralla St., Intramuros, Manila 1002 Philippines

2National Research Institute of Chinese Medicine, No 155-1, Sec. 2, Li-Nung St., Taipei 112, Taiwan

3Chemistry Department and Center for Natural Sciences and Ecological Research, De La Salle University, 2401 Taft Avenue, Manila 1004 Philippines


The leaves of Broussonetia luzonicus afforded epitaraxerol (1), lupenone (2), squalene (3), β-carotene (4), vitamin
K (5) and β-sitosterol (6), while the flowers yielded 2, 6, lupeol (7), betulin aldehyde fatty acid ester (8) and lupeol
fatty acid ester (9). The compounds were isolated by silica gel chromatography and identified by NMR spectroscopy. Triterpenes 1, 2 and 8 were tested for cytotoxicity using the MTT assay. They did not exhibit cytotoxic effect against a human cancer cell line colon carcinoma (HCT 116). Results of the antimicrobial tests on 1, 2 and 8 indicated moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis.
Keywords: Broussonetia luzonicus, Moraceae, triterpenes, antimicrobial


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