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Published on:23rd Nov, 2012
Pharmacognosy Journal, 2012; 4(32):32-37
Research Article | doi:10.5530/pj.2012.32.7

Acetogenins from Annona muricata

Authors and affiliation (s):

Ragasa Consolacion Y1*, Soriano Geneveve1, Torres Oscar B1, Don Ming-Jaw2 and Shen Chien-Chang2

1Chemistry Department and Center for Natural Sciences and Ecological Research, De La Salle University 2401 Taft Avenue, Manila 1004, Philippines

2National Research Institute of Chinese Medicine, 155-1, Li-Nong St., Sec. 2, Taipei 112, Taiwan


Silica gel chromatography of the dichloromethane extract of the seeds of Annona muricata afforded annoreticuin- 9-one (1), while the flesh of the fruit yielded cis-annoreticuin (2) and sabadelin (3). The structures of 1–3 were elucidated by extensive 1D and 2D NMR spectroscopy and confirmed by mass spectrometry. Acetogenins 1 and 2 were first isolated from A. reticulata and A. montana, respectively. Acetogenin 1 was reported to exhibit cytotoxic activities against the human pancreatic tumor cell line (PACA-2), human prostate adenocarcinoma (PC-3) and human lung carcinoma (A-549), while 2 was reported to exhibit cytotoxicity against human hepatoma carcinoma cell line (Hep G2).

Keywords: Annona muricata, annonaceae, annoreticuin-9-one, cis-annoreticuin, sabadelin


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