Pharmacognosy Journal, 2012; 4(32):32-37
Research Article | doi:10.5530/pj.2012.32.7
Acetogenins from Annona muricata
Abstract:
Silica gel chromatography of the dichloromethane extract of the seeds of Annona muricata afforded annoreticuin- 9-one (1), while the flesh of the fruit yielded cis-annoreticuin (2) and sabadelin (3). The structures of 1–3 were elucidated by extensive 1D and 2D NMR spectroscopy and confirmed by mass spectrometry. Acetogenins 1 and 2 were first isolated from A. reticulata and A. montana, respectively. Acetogenin 1 was reported to exhibit cytotoxic activities against the human pancreatic tumor cell line (PACA-2), human prostate adenocarcinoma (PC-3) and human lung carcinoma (A-549), while 2 was reported to exhibit cytotoxicity against human hepatoma carcinoma cell line (Hep G2).
Keywords: Annona muricata, annonaceae, annoreticuin-9-one, cis-annoreticuin, sabadelin
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