Published on:23rd Nov, 2012
Pharmacognosy Journal, 2012; 4(32):29-31
Research Article | doi:10.5530/pj.2012.32.6
Pharmacognosy Journal, 2012; 4(32):29-31
Research Article | doi:10.5530/pj.2012.32.6
Chemical constituents of Aglaia loheri
Abstract:
The dichloromethane extract of the leaves of Aglaia loheri afforded spinasterol (1), trilinolein (2) and phytyl fatty acid ester (3). The structures of 1-2 were identified by comparison of their 13C NMR data with those reported in the literature. Compounds 1, 2 and 3 were evaluated for cytotoxicity against the colon carcinoma (HCT 116) using the MTT assay. They exhibited moderate cytotoxicity against HCT 116 with IC50 values of 40.52, 46.73 and 40.06, respectively.
Keywords: Aglaia loheri, Meliaceae, spinasterol, trilinolein, phytyl fatty acid ester, cytotoxic.
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