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Published on:6th Apr 2010
Pharmacognosy Journal, 2010; 2(7):173–177
Original Article | doi:Nill

Anti-nociceptive and anti-inflammatory activities of Atalantia retusa Merr.

Authors and affiliation (s):

Raga Dennis D.*, Cueto Joey C., Ganacias Richard Lester S., and Mandia Emelina H.

Biology Department and Center for Natural Science and Environmental Research Center, College of Science, De La Salle University, 2401 Taft Ave., Manila 1004 Philippines.


Atalantia retusa is an endemic medicinal plant used in the Philippines. Hexane extract from leaves were orally administered on rats and mice and tested using rat paw edema, formalin and writhing assays. Increased pain tolerance was observed in animals administered with the median dose (1.43 mg/Kg BW) in both somatic (P<0.05) and visceral (P<0.01) models by 6.05% and 55.48% better compared to the positive control. The degree of swelling was also reduced by the administration of 1.43 mg/Kg BW at 0.5 to 3.0h after carrageenan injection suggesting a high impact analgesic and anti-inflammatory effects of A. retusa hexane extract.

Key words: Analgesic, Anti-inflammatory, Rutaceae, hexane extract


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