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Published on:11/2010
Pharmacognosy Journal, 2010; 2(16):53-58
Research Article | doi:10.1016/S0975-3575(10)80050-1

Anti-ulcer activity of cassia auriculata leaf extract


Authors and affiliation (s):

Mohammed Fazil Ahmed*, Hameed Thayyil, Rasheed Ahemad.S and Mohammed Ibrahim

1Nizam Institute of Pharmacy & Research Center, Deshmukhi, Pochampally (M), Near Ramoji Film City, Nalgonda,(AP), INDIA-508284. & Center for Liver Research and Diagnostics, Deccan College of Medical Sciences and Allied Hospitals Kanchanbagh, Hyderabad, Andhra Pradesh, 500 058, India

Abstract:

The present study was carried out to evaluate the anti-ulcer activity of cassia auriculata leaf extract against pylorousligation induced gastric ulcer. The methanolic leaf extract of cassia auriculata at dose of 300 mg/kg p.o. markedly decrease the incidence of ulcers in pyloric ligatied rats. In pyloric ligated rats, there was an increase in the gastric volume, free and total acidity and ulcerative index as compared to the control group. The methanolic leaf extract of cassia auriculata at dose of, 300 mg/kg showed significant reduction in the above parameters which was comparable to the standard drug famotidine(10 mg/kg). Cassia auriculata extract showed protection index 79.4 %, whereas standard drug famotidine showed protection index 90.7%.

Key words: Cassia auriculata, Methanolic extract, Anti-ulceractivity, Pylorous ligation induced gastric ulcer and Famotidine

 

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