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Published on:10th sep 2010
Pharmacognosy Journal, 2010; 2(14):27-32

Antidiabetic Activity and Phytochemical Screening of Crude Extract of Stevia Rebaudiana in Alloxan-induced DiabetiisRats

Authors and affiliation (s):

R.S.Kujur1, Vishakha Singh1, Mahendra Ram1, Harlokesh Narayan Yadava2, K.K.Singh3, Suruchi Kumari1 and B.K.Roy1*

1Dept. of Pharmacology & Toxicology, College of Veterinary Science & A.H.,Birsa Agricultural University, Ranchi – 834006, India.

2Dept. of Pharmacology, I.S.F. College of Pharmacy, Moga-142001, Punjab, India

3 Dept. of veterinary Pathology, College of Veterinary Science & A.H., Birsa Agricultural University, Ranchi – 834006, India.


Results of phytochemical tests showed presence of different kinds of phyto-constituents in aqueous, ether and methanol extract of Stevia rebaudiana leaves. Daily single dose (2.0 g/kg) administration of aqueous extract (A.E.), ether extract (E.E.) and methanol extract (M.E.) for 28 days of S. rebaudiana could not show any significant change in ALT and AST levels in rats. Blood sugar level was found to be decreased on day 28 in groups of rats treated with A.E., E.E. and M.E. of S. rebaudiana.

Key words: Stevia rebaudiana, Aqueous Extract, Ether Extract, Methanol Extract, Diabetes, Sub-acute toxicity, Rats.


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