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Published on:September
Pharmacognosy Journal, 2009; 1():143–145
| doi:

Preparation and Evaluation of Cordia Fruit Gum as Tablet Binder


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Abstract:

In the present work, we have formulated the oral tablets of paracetamol by using cordial fruit gum as a binder. The four different tablet formulations were prepared by wet granulation method. The binder concentrations used in the formulation were 2, 4, 6 & 8 % w/w. The evaluation of granules showed 0.643 to 0.746 mm granule size, 26.65 to 32.10 ° angles of repose and 21.8 to 13.4 % fines. Tablets were compressed to hardness at about 7.5 to 8.2 kg/cm2. The evaluation of tablet showed 1.58 to 1.10 % friability, 12 to 22 min disintegration time and more than 90 % dissolution in 75 min. Tablets at 6 % w/w binder concentration showed more optimum results as tablet binder. The cordial fruit gum was found to be useful for the preparation of uncoated tablet

 

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