Home | Articles
Published on:
Pharmacognosy Journal, 2009; 1(2):143-145
Research Article | doi:Nill

Preparation and Evaluation of Cordia Fruit Gum as Tablet Binder


Authors and affiliation (s):

Patil D.N.1*, Kulkarni A.R.2, Hatapakki B.C.1 and Patil B.S.3

1Department of Pharmacognosy & Phytochemistry, K.L.E.S’s, College of Pharmacy, Gadag - 582101., Karnataka (India)

2Department of Pharmacology, K.L.E.S’s, College of Pharmacy, Belgaum-590041. Karnataka (India)

3Department of Pharmacognosy, SET’s, College of Pharmacy, Dharwad. Karnataka (India).

Abstract:

In the present work, we have formulated the oral tablets of paracetamol by using cordial fruit gum as a binder. The four different tablet formulations were prepared by wet granulation method. The binder concentrations used in the formulation were 2, 4, 6 & 8 % w/w. The evaluation of granules showed 0.643 to 0.746 mm granule size, 26.65 to 32.10 ° angles of repose and 21.8 to 13.4 % fines. Tablets were compressed to hardness at about 7.5 to 8.2 kg/cm2. The evaluation of tablet showed 1.58 to 1.10 % friability, 12 to 22 min disintegration time and more than 90 % dissolution in 75 min. Tablets at 6 % w/w binder concentration showed more optimum results as tablet binder. The cordial fruit gum was found to be useful for the preparation of uncoated tablet dosage form.

Key words: Cordia fruit gum, Binder, Paracetamol and Dissolution.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.




 

Article Links