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Pharmacognosy Journal, 2009; 1(2):143-145
Research Article | doi:Nill

Preparation and Evaluation of Cordia Fruit Gum as Tablet Binder

Authors and affiliation (s):

Patil D.N.1*, Kulkarni A.R.2, Hatapakki B.C.1 and Patil B.S.3

1Department of Pharmacognosy & Phytochemistry, K.L.E.S’s, College of Pharmacy, Gadag - 582101., Karnataka (India)

2Department of Pharmacology, K.L.E.S’s, College of Pharmacy, Belgaum-590041. Karnataka (India)

3Department of Pharmacognosy, SET’s, College of Pharmacy, Dharwad. Karnataka (India).


In the present work, we have formulated the oral tablets of paracetamol by using cordial fruit gum as a binder. The four different tablet formulations were prepared by wet granulation method. The binder concentrations used in the formulation were 2, 4, 6 & 8 % w/w. The evaluation of granules showed 0.643 to 0.746 mm granule size, 26.65 to 32.10 ° angles of repose and 21.8 to 13.4 % fines. Tablets were compressed to hardness at about 7.5 to 8.2 kg/cm2. The evaluation of tablet showed 1.58 to 1.10 % friability, 12 to 22 min disintegration time and more than 90 % dissolution in 75 min. Tablets at 6 % w/w binder concentration showed more optimum results as tablet binder. The cordial fruit gum was found to be useful for the preparation of uncoated tablet dosage form.

Key words: Cordia fruit gum, Binder, Paracetamol and Dissolution.


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