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FREE RADICALS AND ANTIOXIDANTS, 2013; 3(1):40-42
Short Communication | doi:10.1016/j.fra.2013.04.003

Radical scavenging ability of glycyrrhizin


Authors and affiliation (s):

Kimie Imai*, Yushi Takagi, Ayano Iwazaki, Kunio Nakanishi

Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan

Abstract:

Glycyrrhizin (Gly), a major constituent of licorice root, has been used for the treatment of chronic liver diseases in Japan. Reports have been contradictory as to whether Gly scavenges hydroxyl radicals and superoxide anion radicals.We examined the radical scavenging abilities of Gly and glycyrrhezic acid (GA), an aglycon of Gly. Gly and GA did not scavenge hydroxyl radicals or superoxide anion radicals, but both scavenged 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, in contrast to previous reports. The scavenging abilities of Gly and GA might play a role in the treatment of chronic liver diseases.

Key words: Glycyrrhizin (Gly,) Glycyrrhezic acid (GA), Hydroxyl radica,l Superoxide, anion radical, 1,1-Diphenyl-2-picrylhydrazyl (DPPH).

 

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