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Basic Research Article | doi:10.5530/ax.2012.2.2.9

Antioxidant and anti-inflammatory activity of Alstonia scholaris R.Br. stem bark extract

Authors and affiliation (s):

Chandrashekar Kodangala Subraya,1 Harikiran,2 Daksha Gupta1

1Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal - 576104,India

2Department of Pharmacognosy, NitteGulabhiShetty Memorial Institute of Pharmaceutical Sciences, Deralakatte, Mangalore - 574160, India.


Background: The plant Alstonia scholaris R.Br. (Labiatae) is widely cultivated throughout India. The bark of this tree is medicinally used as an astringent, tonic, anthelmintic, antiperiodic and febrifuge. Methods: The effect of Methanolic extract of stem bark of Alstonia scholaris R.Br. was investigated to evaluate the antioxidant activity by TLC method and anti-inflammatory activity by Carrageenan induced rat paw odema, dextran induced rat paw odema and cotton pellet induced granuloma. Result: Anti-inflammatory activity of the tested extract and its fractions was comparable with that of the standard drug Indomethacin (10 mg/kg). Conclusion: The present investigation for the first time, confirms the potential anti-inflammatory activity in the methanol extract of Alstonia scholaris stem bark. Antioxidant property of the extract was confirmed quantitatively by β-carotene–linoleate oxidation method by thin layer chromatography.

Key words: anti-inflammatory activity, Alstonia scholaris, dextran.


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