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Short Communication | doi:10.5530/ax.2012.2.2.8

Antioxidant and antimicrobial activities of Callistemon comboynensis essential oil

Authors and affiliation (s):

Mohamed I. Abdelhady a,b* and Hamdy A. H. Alyc

aDepartment of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, P.O. Box 715, Saudi Arabia;

bPharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt;

cEnvironmental Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), Sadat city – Menofia University – Egypt. P.O. Box 79.


Introduction: The genus Callistemon is known in folk medicine for its anticough, antibronchitis, and insecticidal effects and its volatile oils have been used as antimicrobial and antifungal agents. Methods: The essential oils obtained by hydrodistillation of the leaves of Callistemon comboynensis (Cc) was investigated by GC/MS. Antioxidant activity of Cc was investigated using 1,1-diphenyl-2-picrylhydrazyl (DPPH). The antimicrobial activity of the essential oil of Cc was evaluated against both gram positive (Bacillus subtilis and Staphylococcus aureus), gram negative (Proteus vulgaris, Pseudomonas aeruginosa) and a pathogenic fungus Candida albicans. Results: It was found that Cc afford 0.22% volatile oil. The major components of the volatile oil of Cc are 1, 8-cineol (53.03%), eugenol (12.1%), methyl eugenol (9.2%) and α-pinene (8.3%). The oil had pronounced antibacterial and antifungal activities on all the tested microbes. Nevertheless, Cc leaf oil extract exhibited high antioxidant activity (91.1 ± 0.3 %) at a concentration of 1000 μg.ml-1, comparable to 100 μg.ml-1 gallic acid (95.7 ± 2).

Key Words: C. comboynensis, essential oil, cineole, antioxidant, and antimicrobial activity.


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