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Basic Research Article | doi:10.5530/ax.2012.2.2.12

Quantification of phytochemical constituents and in vitro antioxidant activity of Synadium grantii

Authors and affiliation (s):

Narender Prasad Dasari,* B. Ganga Rao, E. Sambasiva Rao, T. Mallikarjuna Rao, V. S. Praneeth D

AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, AP, India-530 003.


Introduction: In recent years, the search of biologically active compounds from plants has always been of great interest to scientists looking for new sources of useful drugs against infectious diseases. In this present study we investigated quantification of total phenolic, alkaloid content and in vitro antioxidant activity of ethanol (70%), methanol, ethyl acetate and hexane extracts of Synadium grantii. Methods: The quantification of the total phenolic and alkaloid contents were estimated by taking gallic acid and atropine are as a standards, in vitro antioxidant activity was evaluated for extracts by using different free radicals (superoxide, hydroxyl and DPPH). Results: Synadium grantii methanol extract have more phenolic and ethyl acetate alkaloid content than other extracts. The selected plant extracts were produced concentration dependent percentage inhibition of different free radicals and produced maximum activity at a concentration of 1280 μg and there after the percentage inhibition were raised gradually to its maximum level with higher concentrations. Conclusion: In the present study, we found that the extracts of Synadium grantii showed good antioxidant activity. Among the four extracts, the ethyl acetate extract showed better activity than others.

Key words: Synadium grantii, phenolic content, alkaloid content, in vitro antioxidant activity..


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