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Short Communication | doi:10.5530/ax.2011.4.11

Study on Anti-oxidant Activity of Unripe Fruit of Ficus glomerata (Roxb.) using In-vitro Models

Authors and affiliation (s):

Yusufuddin Irfan1, Mohd Asif khan2, Shivakumar H.3

1Dept. of Pharmacology, S.C.S. College of Pharmacy, Harapanahalli, Davangere Dist. (Karnataka) 583131. India

2Dept. of Pharmacology, Faculty of Pharmacy, VCTE, Bijnor- 246701 (U.P.) India.

3Dept. of Pharmacology, Faculty of Pharmacy, BLD University, Bijapur – 586101, (Karnataka), India


Cellular damage or oxidative injury arising from free radicals or reactive oxygen species (ROS) now appears the fundamental mechanism underlying a number of human neurodegenerative disorders, diabetes, inflammation, viral infections, autoimmune pathologies and digestive system disorders. Free radicals are generated through normal metabolism of drugs, environmental chemicals and other xenobiotics as well as endogenous chemicals, especially stress hormones (adrenalin and noradrenalin). Accumulated evidence suggests that ROS can be scavenged through chemoprevention utilizing natural antioxidant compounds present in foods and medicinal plants. India is blessed with enormous biodiversity resources, but plagued with several diseases, including those with ROS as the etiological factor. The present study was designed to evaluate the antioxidants activities of unripe fruits of Ficus glomerata Roxb and three complementary test systems, namely superoxide anion scavenging activity, reducing power, hydroxyl radical scavenging activity were used for the antioxidant analysis. In this study Ficus glomerata exhibited strong antioxidant activity.

Key words: Ficus glomerata, reducing power, hydroxyl radical, superoxide anion, antioxidant.


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