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Published on:8th April 2014
Pharmacognosy journal, 2014; 6(3):55-61
Original Article | doi:10.5530/pj.2014.3.9

Anti-inflammatory and hepatoprotective activities of methanolic extract of Anthemis scrobicularis herbs


Authors and affiliation (s):

Hasan S. Yusufoglu1,*, Aftab Alam1, Mohamad Ayman A. Salkini1, Ahmed M. Zaghloul1, 2

1Pharmacognosy Dept. College of Pharmacy - Salman Bin Abdulaziz University, Al-Kharj, KSA

2Pharmacognosy Department, College of Pharmacy, Mansoura University, Egypt.

Abstract:

The anti-inflammatory and hepatoprotective activitiesof the methanolic extract of Anthemis scrobicularis(ANS) herbs were evaluated in rats against carrageenan induced inflammation and carbon tetrachloride (CCl4)induced hepatic injury. To evaluate the anti-inflammatory effects of ANS, twenty male rats were divided into four equal groups. Injection of 100 μl carrageenan in normal saline into the subplantar region of the hind paw of rats clearly induced paw edema. The volume of paw edema was attenuated following oral administration of ANS. For hepatoprotective effects, twenty five rats were equally divided into five groups.The hepatotoxicity, induced by a single dose of CCl4, produced significant (p<0.001) increase of the levels of serumtransaminase, phosphatase, bilirubin and a decrease in proteins were also noticed. The oxidative stress marker such as malondialdehyde (MDA)was increased and nonprotein sulfhydryl (NP-SH) was decreased in the hepatotoxic tissues. Pre-medication of CCl4-intoxicated rats with ANS at the doses 250 and 500 mg/kg reversed the abnormal liver diagnostic stricture. The results showed that ANS is toxicologically safe when orally administered and possess highly significant anti-inflammatory and hepatoprotective activities and the potentials usefulness of Anthemis scrobicularis in hepatic and inflammatory disease.

Key words: Anthemis scrobicularis, Anti-inflammatory, Hepatoprotective, Carbon tetrachloride, Histopathology.

 

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