Pharmacognosy Communications, 2012; 2(2):67-70
Research Article | doi:10.5530/pc.2012.2.10
Hepatoprotective activity of Santolina chamaecyparissus Linn against D-Galactosamine Induced Hepatotoxicity in Rats
Abstract:
Background: Santolina chamaecyparissus Linn. is used traditionally in Ayurvedic system of medicine in India for the treatment of liver diseases, and as a liver tonic. Methods: The hydroalcoholic extract of Santolina chamaecyparissus Linn. whole plant was tested for its hepatoprotective effect against D-galactosamine induced hepatic damage in rats at a dose of 250°mg/kg. Results: The substantially elevated levels of aspartate amino transferase (ASAT), alanine amino transferase (ALAT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), total cholesterol (TC), triglycerides (TGL), total protein (TP) and albumin (TA) were restored significantly (p<0.001) by the extract The hepatoprotective effect was comparable to that of standard silymarin. Results of histopathological studies supported these findings. Conclusion: It can be concluded from the present study that, the hydroalcoholic extract of Santolina chamaecyparissus Linn. has appreciable hepatoprotective potential.
KEYWORDS: D-galactosamine, flavanoids, hepatoprotective effect, histopathological studies, Santolina chamaecyparissus.
Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.
-
Vancouver Style:
Hepatoprotective activity of Santolina chamaecyparissus Linn against D-Galactosamine Induced Hepatotoxicity in Rats. Pharmacognosy Communications. 2012;2(2):67-70. Abstract
AMA Style:
"Hepatoprotective activity of Santolina chamaecyparissus Linn against D-Galactosamine Induced Hepatotoxicity in Rats." Pharmacognosy Communications. 2012;2(2):67-70. Abstract
CSE Style:
.
2012. Hepatoprotective activity of Santolina chamaecyparissus Linn against D-Galactosamine Induced Hepatotoxicity in Rats. Pharmacognosy Communications. 2(2):67-70. Abstract
- Anti-Nociceptive Synergism of Pregabalin and Xylopic acid Co-administration in Paclitaxel-induced Neuropathy: Isobolographic Analysis
- In vivo Antimalarial Evaluation of Embelin and its Semi-Synthetic Aromatic Amine Derivatives
- Upcoming Events
- In vitro effect of Citrullus colocynthis and Acacia raddiana on Phosphate Calcium Crystallization