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Published on:2nd July 2014
Pharmacognosy Journal, 2014; 6(5):9-14
Original Article | doi:10.5530/pj.2014.5.3

Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity


Authors and affiliation (s):

Noor Kamil1, Hafiz Syed Imran-ul-Haque2

1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982-KSA,

2Department of Pharmacology, Dow International Medical College, Dow University of Health Sciences, Karachi-Pakistan.

Abstract:

Objective: In this study anti-tubercular drugs (isoniazid and rifampicin) induced liver toxicity has been studied for the hepatoprotective effect of hydroethanolic extract of Calotropis procera (CP) flowers in rats. Materials and Method: Animals were divided into four groups, group Awas given normal saline (1ml/kg), group B received Isoniazid (INH) (50mg/kg) and Rifampicin (RMP)(100mg/kg) group C received INH (50mg/kg), RMP(100mg/kg) and CP(150mg/kg)orally for fourteen days. Results: Biochemical markers of liver toxicity such as AST,ALT,ALP, bilirubin and tissue histology were done inall groups. Anti-Tubercular (Anti-TB) drugs (INH 50mg/kg and RMP100mg/kg) have enhanced the ALT, AST, ALP, bilirubin and histological changes in liver, whereas co-administration of anti-TB drugs with Calotropis procera has reduced these levels within the normal range. Conclusion: Findings of this study showed the hepatoprotective effct of Calotropis Proceraagainst Isoniazid and Rifampicinadministration to reduce the liver damage for chronic treatment.

Key words: Isoniazid, Rifampicin, Calotropis procera, Hepatoprotective.

 

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