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Chemical constituents of Artocarpus camansi
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Published on:
Pharmacognosy Journal, 2013; 5(2):80-82
Short Communication | doi:10.1016/j.phcgj.2012.06.001

Chemical constituents of Artocarpus camansi


Authors and affiliation (s):

Po-Wei Tsaia, Kathlia A. De Castro-Cruzb, Chien-Chang Shenc, Chun-Tang Chioud, Consolacion Y. Ragasae,*

aSchool of Chemical Engineering and Chemistry, Mapúa Institute of Technology, Intramuros, Manila 1002, Philippines

bProfessor, School of Chemical Engineering and Chemistry, Mapúa Institute of Technology, Intramuros, Manila 1002, Philippines

cAssociate Research Fellow, National Research Institute of Chinese Medicine, Taipei 112, Taiwan

dAssistant Research Fellow, National Research Institute of Chinese Medicine, Taipei 112, Taiwan

eProfessor, Chemistry Department, Center for Natural Sciences and Ecological Research, De La Salle University, Manila 1004, Philippines

Abstract:

The dichloromethane extract of the leaves of Artocarpus camansiafforded friedelinol (1), squalene (2), bsitosterol (3), stigmasterol (4) and phytol (5), while the stems yielded polyprenol (6), cycloartenol (7) and cycloartenol acetate (8). The structures of 1, 7 and 8 were elucidated by extensive 1D and 2D NMR spectroscopy. The cytotoxicity of these triterpenes were tested using the sulforhodamine B assay against the human cancer cell lines: lung adenocarcinoma A549 cells, stomach adenocarcinoma AGS cells, colon adenocarcinoma HT29 cells and prostate cancer PC3 cells. Results of the study indicated that 1, 7 and 8 are non-cytotoxic against these cell lines.

Key words: Artocarpus camansi ,Moraceae Friedelinol ,Cycloartenol acetate, Cycloartenol

 

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