Pharmacognosy Journal, 2013; 5(2):80-82
Short Communication | doi:10.1016/j.phcgj.2012.06.001
Chemical constituents of Artocarpus camansi
The dichloromethane extract of the leaves of Artocarpus camansiafforded friedelinol (1), squalene (2), bsitosterol (3), stigmasterol (4) and phytol (5), while the stems yielded polyprenol (6), cycloartenol (7) and cycloartenol acetate (8). The structures of 1, 7 and 8 were elucidated by extensive 1D and 2D NMR spectroscopy. The cytotoxicity of these triterpenes were tested using the sulforhodamine B assay against the human cancer cell lines: lung adenocarcinoma A549 cells, stomach adenocarcinoma AGS cells, colon adenocarcinoma HT29 cells and prostate cancer PC3 cells. Results of the study indicated that 1, 7 and 8 are non-cytotoxic against these cell lines.
Key words: Artocarpus camansi ,Moraceae Friedelinol ,Cycloartenol acetate, Cycloartenol
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