Pharmacognosy Journal, 2013; 5(3):127-129
Short Communication | doi:10.1016/j.phcgj.2013.04.005
Cytotoxic effect of Anthocephalus cadamba Miq. leaves on human cancer cell lines
Introduction: Anthocephalus cadamba Miq. (Rubiaceae) is used as folk medicine in the treatment of fever, anemia, leprosy, dysentery, blood and skin diseases. Methods: Powdered leaves of A. cadamba were extracted sequentially with hexane, chloroform, ethanol, ethanol:water (50:50) and water by maceration, and evaluated for cytotoxic potential using SRB assay against four human cancer cell lines lung (A-549), ovary (IGR-OV-1), prostate (PC-3) and CNS (SF-295). Results: Chloroform extract exerts potent cytotoxic effect against human lung (A-549), ovary (IGR-OV-1), prostate (PC-3) and CNS (SF-295) cancer cell lines IC50 of 8, 57, 49 and 39 mg/ml respectively. Ethanolic extract was found to be active only against one cell line CNS (SF-295). Conclusion: The present study demonstrates the cytotoxic potential of A. cadamba leaves extract (chloroform) against different human cancer cell lines.
Key words: Anthocephalus cadamba,Cytotoxicity,Rubiaceae,Lung (A-549).
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