Pharmacognosy Journal, 2013; 5(3):113-118
Original Article | doi:10.1016/j.phcgj.2013.05.003
Psychopharmacological and antioxidant effects of hydroethanolic extract of Alpinia zerumbet leaves in mice
Background: Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm., Zingiberaceae, is traditionally used in Brazil to treat hypertension, inflammation, anxiety, and hysteria. However, investigations of antioxidant and central effects of A. zerumbet extract are lacking. Objective: The aim of this study was to verify the effects of a hydroethanolic extract of A. zerumbet (HEA) on tail suspension and light/dark tests to screen for possible antidepressant- and anxiolytic-like activities, respectively. We also evaluated the in vitro antioxidant effects of HEA. Materials and methods: Swiss male mice were orally treated with saline or HEA (200, 400 or 800 mg/kg) 60 min before testing. The in vitro antioxidant activity of HEA was determined using the ferric-reducing antioxidant property method and assays involving free radical and reactive oxygen species scavenging. Protections against glutathione oxidation and lipid peroxidation were also evaluated. Results: HEA (200, 400 and 800 mg/kg) significantly reduced the period of immobility in the tail suspension test, similarly to imipramine. In the tail suspension test, HEA (400 and 800 mg/kg but not 200 mg/kg) and diazepam significantly increased time spent in the light side. The antioxidant activity of HEA was remarkable, as it showed significant ferric-reduction power, 1,1-diphenyl-2-picrylhydrazyl radical and hydrogen peroxide scavenging activity, and protection against lipid peroxidation. Conclusion: This study showed the antioxidant, antidepressant- and anxiolytic-like effects of HEA in mice. More studies and the identification of active components of the extract are necessary to further assess the therapeutic potential of this species in the treatment of psychiatric diseases.
Key words: Alpinia zerumbet, Antioxidant activity, Anxiety, Depression, Mice.
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