Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:62:\"Non-static method view::load() should not be called statically\";s:5:\"%file\";s:63:\"/home/phcogfir/public_html/sites/all/modules/views/views.module\";s:5:\"%line\";i:1118;}', 3, '', 'https://phcogfirst.com/article/218', '', '3.238.96.184', 1620758727) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:109:\"Declaration of views_handler_field::query() should be compatible with views_handler::query($group_by = false)\";s:5:\"%file\";s:83:\"/home/phcogfir/public_html/sites/all/modules/views/handlers/views_handler_field.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/218', '', '3.238.96.184', 1620758727) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:136:\"Declaration of views_handler_argument::options_validate() should be compatible with views_handler::options_validate($form, &$form_state)\";s:5:\"%file\";s:86:\"/home/phcogfir/public_html/sites/all/modules/views/handlers/views_handler_argument.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/218', '', '3.238.96.184', 1620758728) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:112:\"Declaration of views_handler_argument::query() should be compatible with views_handler::query($group_by = false)\";s:5:\"%file\";s:86:\"/home/phcogfir/public_html/sites/all/modules/views/handlers/views_handler_argument.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/218', '', '3.238.96.184', 1620758728) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:134:\"Declaration of views_handler_filter::options_validate() should be compatible with views_handler::options_validate($form, &$form_state)\";s:5:\"%file\";s:84:\"/home/phcogfir/public_html/sites/all/modules/views/handlers/views_handler_filter.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/218', '', '3.238.96.184', 1620758728) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:110:\"Declaration of views_handler_filter::query() should be compatible with views_handler::query($group_by = false)\";s:5:\"%file\";s:84:\"/home/phcogfir/public_html/sites/all/modules/views/handlers/views_handler_filter.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/218', '', '3.238.96.184', 1620758728) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:127:\"Declaration of views_plugin_query::options_submit() should be compatible with views_plugin::options_submit($form, &$form_state)\";s:5:\"%file\";s:81:\"/home/phcogfir/public_html/sites/all/modules/views/plugins/views_plugin_query.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/218', '', '3.238.96.184', 1620758728) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:139:\"Declaration of views_plugin_argument_validate::options_submit() should be compatible with views_plugin::options_submit($form, &$form_state)\";s:5:\"%file\";s:93:\"/home/phcogfir/public_html/sites/all/modules/views/plugins/views_plugin_argument_validate.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/218', '', '3.238.96.184', 1620758728) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:130:\"Declaration of views_plugin_row::options_validate() should be compatible with views_plugin::options_validate(&$form, &$form_state)\";s:5:\"%file\";s:79:\"/home/phcogfir/public_html/sites/all/modules/views/plugins/views_plugin_row.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/218', '', '3.238.96.184', 1620758728) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135
Acetogenins from Annona muricata
Home | Articles
Published on:23rd Nov, 2012
Pharmacognosy Journal, 2012; 4(32):32-37
Research Article | doi:10.5530/pj.2012.32.7

Acetogenins from Annona muricata


Authors and affiliation (s):

Ragasa Consolacion Y1*, Soriano Geneveve1, Torres Oscar B1, Don Ming-Jaw2 and Shen Chien-Chang2

1Chemistry Department and Center for Natural Sciences and Ecological Research, De La Salle University 2401 Taft Avenue, Manila 1004, Philippines

2National Research Institute of Chinese Medicine, 155-1, Li-Nong St., Sec. 2, Taipei 112, Taiwan

Abstract:

Silica gel chromatography of the dichloromethane extract of the seeds of Annona muricata afforded annoreticuin- 9-one (1), while the flesh of the fruit yielded cis-annoreticuin (2) and sabadelin (3). The structures of 1–3 were elucidated by extensive 1D and 2D NMR spectroscopy and confirmed by mass spectrometry. Acetogenins 1 and 2 were first isolated from A. reticulata and A. montana, respectively. Acetogenin 1 was reported to exhibit cytotoxic activities against the human pancreatic tumor cell line (PACA-2), human prostate adenocarcinoma (PC-3) and human lung carcinoma (A-549), while 2 was reported to exhibit cytotoxicity against human hepatoma carcinoma cell line (Hep G2).

Keywords: Annona muricata, annonaceae, annoreticuin-9-one, cis-annoreticuin, sabadelin

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.




 

Article Links