Pharmacognosy Journal, 2010; 2(13):525-529
Research Article | doi:Nill
Evaluation of Various Natural Gums as Release Modifiers in Tablet Formulations
Background and purpose of study: In the present investigation, sustained release tablets of diclofenac sodium were formulated using guar gum and gum arabic (gum acacia) as release modifier. Methods: Six batches of sustained release matrix tablets of diclofenac sodium were prepared by using different drug:polymer ratios viz., 1:1, 1:1.5, 1:2, 1:2.5, 1:3, and 1:3.5 for both guar gum and gum acacia. The tablets were evaluated for physical characteristics like hardness, weight varia - tion, fraibilty, and drug content. In vitro release of drug was studied in phosphate buffered saline (pH 7.4) for twenty four hours. Results: All the physical characters of the formulated tablets were found to be within acceptable limits. The tablets with guar gum exhibited greater swelling index than those with gum acacia. A better controlled drug release (98.7%) was obtained with the matrix tablet (F1) made-up of the guar gum. Conclusion: It is clear through the dissolution profile of matrix tablets prepared using guar gum and gum acacia that these polymers have ability to retard drug release for 24 hrs.
Key words: Diclofenac sodium, guar gum, gum acacia, sustained release matrix tablets.
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