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Dual effects of (þ)-catechin on hemin-induced oxidative reactions: A potential pharmacological implication
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FREE RADICALS AND ANTIOXIDANTS, 2013; 3(1):11-16
Original article | doi:10.1016/j.fra.2013.04.002

Dual effects of (þ)-catechin on hemin-induced oxidative reactions: A potential pharmacological implication


Authors and affiliation (s):

Nai-Hao Lu a,b,*, Ying-Jie He a,c, Chao Chen a, Rong Tian c, Qiang Xiao b, Yi-Yuan Peng a,c,*

a Key Laboratory of Functional Small Organic Molecule, Ministry of Education and College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, China

b Jiangxi Key Laboratory of Functional Organic Molecules, Jiangxi Science and Technology Normal University, Nanchang 330013, China

c Key Laboratory of Green Chemistry, Jiangxi Province and College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi, 330022, China

Abstract:

Introduction: Although the anti- and pro-oxidant properties were the well-known phenomenons for flavonoids, the influence of flavonoids on free heme-dependent redox reactions was not definitely elucidated. Methods: By spectrophotometry and Western blotting, the influence of (þ)-catechin (a polyphenol identified in red wine, tea, and cocoa) on hemin-induced oxidative reactions was investigated in this study. Results: (þ)-Catechin was found to act as an efficient reducing agent for the reduction of ferryl heme to ferric state, demonstrating novel anti-oxidant pathway. However, this antioxidant had the ability to trigger hemin oxidation through producing additional hydrogen peroxide (H2O2). On the other hand, the effects of (þ)-catechin on hemineH2O2einduced protein (or methylene blue) oxidation depended on the concentrations of H2O2 and antioxidant. (þ)-Catechin exerted significant anti-oxidant ability when lower concentration of H2O2 was used. However, in the presence of higher concentration of H2O2, (þ)-catechin at low concentrations could significantly aggravate oxidative reactions and exhibit protective effects at high concentrations. Conclusions: The anti- and pro-oxidant effects of catechin on heme-dependent redox reactions at different concentration, may provide new insights into the dietary intake and therapeutic implications of catechins with free heme and heme proteins.

Key words: Hemin, (+)-Catechin, Oxidative reactions, Anti-oxidant, Pro-oxidant.

 

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