Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:62:\"Non-static method view::load() should not be called statically\";s:5:\"%file\";s:63:\"/home/phcogfir/public_html/sites/all/modules/views/views.module\";s:5:\"%line\";i:1118;}', 3, '', 'https://phcogfirst.com/article/749', '', '3.238.235.155', 1620403247) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:109:\"Declaration of views_handler_field::query() should be compatible with views_handler::query($group_by = false)\";s:5:\"%file\";s:83:\"/home/phcogfir/public_html/sites/all/modules/views/handlers/views_handler_field.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/749', '', '3.238.235.155', 1620403247) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:136:\"Declaration of views_handler_argument::options_validate() should be compatible with views_handler::options_validate($form, &$form_state)\";s:5:\"%file\";s:86:\"/home/phcogfir/public_html/sites/all/modules/views/handlers/views_handler_argument.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/749', '', '3.238.235.155', 1620403247) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:112:\"Declaration of views_handler_argument::query() should be compatible with views_handler::query($group_by = false)\";s:5:\"%file\";s:86:\"/home/phcogfir/public_html/sites/all/modules/views/handlers/views_handler_argument.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/749', '', '3.238.235.155', 1620403247) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:134:\"Declaration of views_handler_filter::options_validate() should be compatible with views_handler::options_validate($form, &$form_state)\";s:5:\"%file\";s:84:\"/home/phcogfir/public_html/sites/all/modules/views/handlers/views_handler_filter.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/749', '', '3.238.235.155', 1620403247) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:110:\"Declaration of views_handler_filter::query() should be compatible with views_handler::query($group_by = false)\";s:5:\"%file\";s:84:\"/home/phcogfir/public_html/sites/all/modules/views/handlers/views_handler_filter.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/749', '', '3.238.235.155', 1620403247) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:127:\"Declaration of views_plugin_query::options_submit() should be compatible with views_plugin::options_submit($form, &$form_state)\";s:5:\"%file\";s:81:\"/home/phcogfir/public_html/sites/all/modules/views/plugins/views_plugin_query.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/749', '', '3.238.235.155', 1620403247) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:139:\"Declaration of views_plugin_argument_validate::options_submit() should be compatible with views_plugin::options_submit($form, &$form_state)\";s:5:\"%file\";s:93:\"/home/phcogfir/public_html/sites/all/modules/views/plugins/views_plugin_argument_validate.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/749', '', '3.238.235.155', 1620403247) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135

Warning: Table './phcogfir_phcogfs/dr_watchdog' is marked as crashed and should be repaired query: INSERT INTO dr_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:14:\"strict warning\";s:8:\"%message\";s:130:\"Declaration of views_plugin_row::options_validate() should be compatible with views_plugin::options_validate(&$form, &$form_state)\";s:5:\"%file\";s:79:\"/home/phcogfir/public_html/sites/all/modules/views/plugins/views_plugin_row.inc\";s:5:\"%line\";i:0;}', 3, '', 'https://phcogfirst.com/article/749', '', '3.238.235.155', 1620403247) in /home/phcogfir/public_html/includes/database.mysql.inc on line 135
Superoxide Dismutase Ameliorates the Bowel Alterations Induced by Diabetes Mellitus – An Experimental Study
Home | Articles
Published on:
FREE RADICALS AND ANTIOXIDANTS, 2011; 1(3):19-26
Free Radical Biology. | doi:10.5530/ax.2011.3.4

Superoxide Dismutase Ameliorates the Bowel Alterations Induced by Diabetes Mellitus – An Experimental Study


Authors and affiliation (s):

Henrique Fillmann1, Juliana Tieppo1, Nélson Alexandre Kretzmann Filho1, Graziella Rodrigues1, Jaqueline Nascimento Picada2, Julian Panés3, Norma Possa Marroni1,2.

1Hospital de Clínicas de Porto Alegre – Brazil.

2Universidade Luterana do Brasil, ULBRA - Brazil.

3Hospital Clínic. University of Barcelona, Spain

Abstract:

Introduction: The gastrointestinal system is frequently affected in patients with diabetes mellitus (DM). Some of these alterations are due to oxidative stress and the production of free radicals. The present study was designed to evaluate whether treatment with superoxide dismutase (SOD) exerts protection on established bowel alterations in experimental diabetes mellitus induced by streptozotocin. We measured the lipid peroxidation, the superoxide dismutase activity and the DNA damage. Materials and Methods: We used the anorectal pressure to evaluate the nitrosative stress and used an inflammatory score to measure the macroscopic and microscopaic bowel alterations. Results: The oxidative stress and the DNA damage was elevated in DM group and reduced with the SOD administration. The use of SOD also ameliorates the inflammatory bowel alterations and the anorectal pressure. Conclusion: SOD administration showed beneficial effects in all parameters of large bowel alterations in DM rats.

Key words: oxidative stress; diabetes; superoxide dismutase.

 

Articles in PDF, ePUB and Full text are attached to this page. In order to download, print or access these formats you must be logged in.




 

Article Links